Scientific publications

2014, 2015, 2016 Annual progress summaries.

MNM selection, acquisition, engineering, characterisation (WP2)

Jul. 2017 - The effect of zirconium doping of cerium dioxide nanoparticles on pulmonary and cardiovascular toxicity and biodistribution in mice after inhalation. Susan Dekkers, Mark R. Miller, Roel P.F. Schins, Isabella Römer, Mike Russ, Rob J. Vandebriel, Iseult Lynch, Marie-France Belinga-Desaunay, Eugenia Valsami-Jones, Shea P. Connell, Ian P. Smith, Rodger Duffin, John A.F. Boere, Harm J. Heusinkveld, Catrin Albrecht, Wim H. de Jong & Flemming R. Cassee. Nanotoxicology Vol. 0 , Iss. 0,0. 

Jan. 2017 - Development of scalable and versatile nanomaterial libraries for nanosafety studies: polyvinylpyrrolidone (PVP) capped metal oxide nanoparticles. S. M. Briffa, I. Lynch (UoB, UK);   V. Trouillet, M. Bruns (KIT, De); D. Hapiuk, J. Liu, R. E. Palmerc and   E. Valsami-Jones (UoB, UK).  RSC Adv., 2017,7, 3894-3906. 16.01.2017.OPEN ACCESS.

January 2016 - Highly Flexible Platform For Tuning Surface Properties Of Silica Nanoparticles And Monitoring Their Biological Interaction. Ojea-Jimenéz, Isaac; Gilliland, Douglas, JRC, et al. ACS Appl. Mater. Interfaces, 2016, 8 (7), pp 4838–4850. OPEN ACCESS.

July 2015 - Progress towards the validation of modeled environmental concentrations of engineered nanomaterials by analytical measurements. Bernd Nowack and Denise M. Mitrano, EMPA, Switzerland, Jamie Lead (UoB), et al.

April 2015 - Metastability of the atomic structures of size-selected gold nanoparticles. D. M. Wells, R. E. Palmer, University of Birmingham (UK); G. Rossi, R. Ferrando, Università di Genova (It). Nanoscale. 2015 Apr 21;7(15):6498-503.

Life cycle evolution of MNMs (WP3)

January 2017 - The need for a life-cycle based aging paradigm for nanomaterials: importance of real-world test systems to identify realistic particle transformations. D. Mitrano and B. Nowack (EMPA), CH. Nanotechnology, Volume 28, Number 7.

April 2016 - Unraveling the Complexity in the Aging of Nanoenhanced Textiles: A Comprehensive Sequential Study on the Effects of Sunlight and Washing on Silver Nanoparticles. ES&T.D. Mitrano, B. Nowack (EMPA, CH) et al.

April 2016 - Stability of uncoated and fulvic acids coated manufactured CeO2 nanoparticles in various conditions: From ultrapure to natural Lake Geneva waters. Oriekhova, O., Stoll, University of Genova (CH).  Science of Total Environment. 562:327-334.

March 2016 - Durability of nano-enhanced textiles through the life cycle: releases from landfilling after washing. D. Mitrano, B. Nowack (EMPA, CH) et al. Environ. Sci.: Nano.

August 2015 - Effect of Variations of Washing Solution Chemistry on Nanomaterial Physicochemical Changes in the Laundry Cycle. Denise M. Mitrano, Yadira Arroyo Rojas Dasilva, Bernd Nowack, EMPA, Switzerland. Environmental Science and Technology: Environ. Sci. Technol., 2015, 49 (16), pp 9665–9673.

January 2015 - Review of nanomaterial aging and transformations through the life cycle of nano-enhanced products. Denise M. Mitrano (EMPA, CH), Sylvie Motellier and Simon Clavaguera (CEA, Fr), Bernd Nowack (EMPA, CH). Environment International.

September 2014. Are Nanosized or dissolved metals more toxic? A meta-analysis. D. Notter, D. Mitrano, B. Nowack (EMPA). Environ Toxicol Chem. Volume 33, Issue 12 Pages 2733–2739.

June 2014 - Presence of Nanoparticles in Wash Water From Conventional Silver and Nano-Silver Textiles. Denise M. Mitrano, Elisa Rimmele, Adrian Wichser, Rolf Erni, Murray Height, Bernd Nowack, EMPA & HeiQ Materials AG. ACS Nano, 2014, 8 (7), pp 7208–7219. [Work started prior to NanoMILE and continued under NanoMILE].

January 2014 - Cellular self-organization on micro-structured surfaces. Peter J. F. Rottgermann, Alicia Piera Alberola and Joachim O. Radler, Ludwig-Maximilians-Universität (Munich). Soft Matter .

Development of a screeening platform for MNMs (WP4)

Feb. 2017 - Imaging In focus: Reflected light imaging: Techniques and applications. E. J. Guggenheim, I. Lynch (UoB, UK); J. Z. Rappoport (Northwestern University, Chicago, USA). The International Journal of Biochemistry & Cell Biology. Volume 83, February 2017, Pages 65–70.

Nov. 2016 -The Intracellular Destiny of the Protein Corona: A Study on its Cellular Internalization and Evolution. Bertoli F1, Garry D1, Monopoli MP1,2, Salvati A1,3, Dawson KA1. 1 UCD (Ir), 2 Royal College of Surgeons (Ir), 3Groningen Research Institute of Pharmacy (NL). ACS Nano. 2016 Nov 22;10(11):10471-10479.

Oct. 2016 - Comparison of Confocal and Super-Resolution Reflectance Imaging of Metal Oxide Nanoparticles. Emily J. Guggenheim, A. Khan, J. Pike, L. Chang, I. Lynch (UoB, UK); J. Z. Rappoport (Northwestern University, Chicago, USA). PLOS. October 3, 2016.

April 2016 - Time-Resolved Study of Nanoparticle Induced Apoptosis Using Microfabricated Single Cell Arrays. Peter J.F. Röttgermann, Kenneth A. Dawson, Joachim O.Rädler, UCD (Ir) and Ludwig-Maximilians-Universität München (De). Microarrays   MDPI  2016, 5(2). OPEN ACCESS

March 2016 - Versatile method to generate multiple types of micropatterns. Segerer,F.J., Röttgermann,P.J., Schuster,S., Piera,A.A., Zahler,S., and Rädler,J.O. Ludwig-Maximilians-Universität München (De). Biointerphases. 11, 011005.

September 2014 - Cell Motility on Polyethylene Glycol Block Copolymers Correlates to Fibronectin Surface Adsorption. Röttgermann PJ, Hertrich S, Berts I, Albert M, Segerer FJ, Moulin JF, Nickel B, Rädler JO., Ludwig-Maximilians-Universität (Munich) & Helmholtz Zentrum Geesthach. 

MNM interactions with biomolecules and environmental factors (WP5)

May 2016 - Polypeptide-Nanoparticle Interactions and Corona Formation Investigated by Monte Carlo Simulations. Fabrice Carnal, Arnaud Clavier, Serge Stoll (Uni. of Genova, CH). Polymers, Vol. 8, No. 6, 2016 p 203. OPEN ACCESS.

August 2015 - Modelling the interaction processes between nanoparticles and biomacromolecules of variable hydrophobicity: Monte Carlo simulations. Fabrice Carnal, Arnaud Clavier and Serge Stoll, University of Geneva. Environmental Science Nano, Volume 2 Number 4 August 2015, pp327-339 & Cover page. OPEN ACCESS

August 2015 - Isothermal titration calorimetry as a powerful tool to quantify and better understand agglomeration mechanisms during interaction processes between TiO2 nanoparticles and humic acids. Loosli F, Vitorazi L, Berret J-F, Stoll S., University of Genova (CH). Environ. Sci.: Nano, 2015, 2:541-550.

August 2015 - Effects of pH and fulvic acids concentration on the stability of fulvic acids – cerium (IV) oxide nanoparticle complexes. Olena Oriekhova, Serge Stoll, University of Geneva. Chemosphere 144 (2016) 131-137.

December 2014 - Surface charging behavior of nanoparticles by considering site distribution and density, dielectric constant and pH changes - a Monte Carlo approachArnaud Clavier, Marianne Seijo, Fabrice Carnal and  Serge Stoll, University of Geneva (CH). Phys. Chem. Chem. Phys., 2015,17, 4346-4353.

November 2014 - Investigation of FeCl3 induced coagulation processes using electrophoretic measurement, nanoparticle tracking analysis and dynamic light scattering: Importance of pH and colloid surface charge. Oriekhova O, Stoll S., University of Genova (CH).  Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2014, 461:212-219.

November 2014 - Manufactured Nanoparticle Behavior and Transformations in Aquatic Systems. Importance of Natural Organic Matter. Loosli F, Omar FM, Carnal F, Oriekhova O, Clavier A, Chai Z, Stoll S, University of Genova (CH). Chimia. 2014, 68: 783-787.

October 2014 - Surfactant Titration of Nanoparticle−Protein Corona. Daniele Maiolo, Paolo Bergese, Eugene Mahon, Kenneth A. Dawson, and Marco P. Monopoli, University College Dublin, University of Brescia. Analytical Chemistry, 28/10/2014. [Work started prior to NanoMILE and continued under NanoMILE]

January 2014 - Effect of natural organic matter on the disagglomeration of manufactured TiO2 nanoparticles. Loosli F, Le Coustumer P, Stoll S., University of Genova (CH). Environ. Sci.: Nano, 2014, 1:154-160. OPEN ACCESS.

MNM interactions, bioavailability & biological effects in vitro/in vivo (ecotoxicology) (WP6)

Nov. 2016 - Sensory systems and ionocytes are targets for silver nanoparticle effects in fish. O.J. Osborne, T. Kudoh, Charles C.R. Tyler (U. of Exeter, UK); I. Romer, U. Phillips, I. Lynch (UoB, UK); et al. Nanotoxicology. 2016 Nov;10(9):1276-86.

November 2015 - In vivo toxicity and gill histological damage of copper nanoparticles in rainbow trout, fathead minnow and zebrafish. Lan Song, Martina G. Vijver, Willie J.G.M. Peijnenburg, Tamara S. Galloway, University of Leiden (NL, with FP7 project QualityNano); Charles R. Tyler, University of Exeter (UK). Chemosphere. 139:181-9.

May 2015 - Tracing Engineered Nanomaterials in Biological Tissues using Coherent Anti-strokes Raman Scattering- A Critical Review. Goodhead R.M., Moger, J., Galloway, T.S., Tyler C.R, University of Exeter (UK). Nanotoxicology 9(7):928-39.

2015 - Ecotoxicology of Nanomaterials in Aquatic Systems. Jennings, V., Goodhead, R.M., Tyler CR, University of Exeter (UK). Chapter 1 (pp 3-45) of the book “Characterization of Nanomaterials in Complex Environmental and Biological Media”. Frontiers of Nanoscience, Elsevier.

February 2014 - Linking toxicity and adaptive responses across the transcriptome, proteome, and phenotype of Chlamydomonas reinhardtii exposed to silver, S Pillai, K. Schirmer et al., EAWAG (CH),  PNAS 111 (9), 3490-3495.

August 2013 - Effect of Ingested Tungsten Oxide (WOx) Nanofibers on Digestive Gland Tissue of Porcellio scaber (Isopoda, Crustacea): Fourier Transform Infrared (FTIR) Imaging. Novak S, Drobne D, Vaccari L, Kiskinova M, Ferraris P, Birarda G, Remskar M, Hocevar, M. University of Lubjana (Sl). Environ. Sci. Technol., 2013, 47:11284–11292.

MNM biokinetics and toxicity testing in vitro/in vivo (human toxicology) (WP7)

July 2017 -  Crystallinity depends on choice of iron salt precursor in the continuous hydrothermal synthesis of Fe–Co oxide nanoparticles. Jan Liu, Isabella Römer, Selina Vi Yu Tang, Eugenia Valsami-Jones and Richard E. Palmer. Royal Society of Chemistry.  Volume 7, 37436 - 37440. OPEN ACCESS

Nov. 2016 - Comparison of the DNA damage response in BEAS-2B and A549 cells exposed to titanium dioxide nanoparticles. M. Biola, D. Beal, S. Caillat, S. Libert, L. Armand, N. Herlin-Boime, S. Sauvaigo, T. Douki, M. Carriere (CEA). Mutagenesis (2017) 32 (1): 161-172. 01.11.2016.

Oct. 2016 - Impact of nanoparticles on DNA repair processes: current knowledge and working hypotheses. M. Carriere, S. Sauvaigo, T. Douki, J.-L. Ravanat (CEA). Mutagenesis (2017) 32 (1): 203-213. 28.10.2016.

April 2016 – An update on NLRP3 inflammasome activation by engineered nanomaterials. R.J. Vandebriel, S. Dekkers, W.H de Jong, F.R. Cassee, RIVM. Current Bionanotechnology, Vol 2 issue 1 (2016), pp 40-46. OPEN ACCESS.

February 2016 -  Long-term exposure of A549 cells to titanium dioxide nanoparticles induces DNA damage and sensitizes cells towards genotoxic agents. Lucie Armand, Adeline Tarantini, David Beal, Mathilde Biola-Clier, Laure Bobyk (Univ. Grenoble - CEA, Fr); Sephanie Sorieul (Univ. Bordeaux); Karin Pernet-Gallay (Univ. Grenoble - INSERM); Caroline Marie-Desvergne (Univ. grenoble - CEA, Fr), Iseult Lynch (UoB, UK), Nathalie Herlin-Boime (CEA - CNRS, Fr);  Marie Carriere (Univ. Grenoble - CEA, Fr). Nanotoxicology.

August 2015 - Molecular responses of alveolar epithelial A549 cells to chronic exposure to titanium dioxide nanoparticles: A proteomic view. Lucie Armand, Mathilde Biola-Clier, Laure Bobyk (Univ. Grenoble - CEA, Fr); Véronique Collin-Faure (CEA, Fr); Hélène Diemer, Jean-Marc Strub, Sarah Cianferani, Alain Van Dorsselaer (UNi. Strasbourg - CNRS, Fr); Nathalie Herlin-Boime (CEA-CNRS, Fr); Thierry Rabilloud (CNRS, Fr), Marie Carriere (Univ. Grenoble - CEA, Fr). Journal of Proteomics, Volume 134, 16 February 2016, Pages 163–173.

October 2014 - Time course of lung retention and toxicity of inhaled particles: short‑term exposure to nano‑Ceria. Jana Keller, Wendel Wohlleben, Lan Ma‑Hock, Volker Strauss, Sibylle Gröters, Karin Küttler, Karin Wiench, Christiane Herden, Günter Oberdörster, Bennard van Ravenzwaay, Robert Landsiedel, BASF, Justus-Liebig-University (Giessen) & University of Rochester. Arch. of Toxicol.

September 2014 -  High Content Analysis Provides Mechanistic Insights on the Pathways of Toxicity Induced by Amine-Modified Polystyrene Nanoparticles. Sergio Anguissola, David Garry, Anna Salvati, Peter J. O'Brien, Kenneth A. Dawson,  University College Dublin (Ir). Plos one, Volume 9, Issue 9, e108025.

May 2014 - Carbon Nanotube Translocation to Distant Organs after Pulmonary Exposure: Insights from in Situ 14C‑Radiolabeling and Tissue Radioimaging. Bertrand Czarny, Dominique Georgin, Fannely Berthon, Gael Plastow, Mathieu Pinault, Gilles Patriarche, Aurélie Thuleau, Martine Mayne L’Hermite, Frédéric Taran, and Vincent Dive, CEA - CNRS. ACS Nano.

June 2013 - In vivo nanotoxicity testing using the zebrafish embryo assay. Hennink WE, Storm G,  Lammers T., U. of Utrecht (NL), et al. J Mater Chem B Mater Biol Med, 2013, 1: 3918-3925. OPEN ACCESS

Data integration, QPARs, risk assessment, safe MNM designs (WP9)

October 2015 - How safe are nanomaterials? Eugenia Valsami-Jones and Iseult Lynch, University of Birmingham (UK). Science. Vol 350 issue 6259. OPEN ACCESS Version.

April 2015 - Risk Assessment Tool for the Virtual Screening of Metal Oxide Nanoparticles through Enalos InSilicoNano Platform. Georgia Melagraki and Antreas Afantitis, Novamechanics Ltd (Cyprus). Current Topics in Medicinal Chemistry, 2015, 15, 1827-1836.

March 2015 - Nanomaterial categorization for assessing risk potential to facilitate regulatory decision-making. Godwin H; I. Lynch, University of Birmingham (UK); et al.ACS Nano. 2015, 9:3409-3017.

February 2015 - Quantitative Nanostructure-Activity Relationship models for the Risk Assessment of NanoMaterials. Chapter in the book "Quantitative Structure-Activity Relationships in Drug Design, Predictive Toxicology, and Risk Assessment". Ed. IGI Global. Eleni Vrontaki (NovaMechanics Ltd., Cyprus & University of Athens, Greece), Thomas Mavromoustakos (University of Athens, Greece), Georgia Melagraki (NovaMechanics Ltd., Cyprus) and Antreas Afantitis (NovaMechanics Ltd., Cyprus).

September 2014 - Enalos InSilicoNano platform: an online decision support tool for the design and virtual screening of nanoparticles. Georgia Melagraki and Antreas Afantitis, Novamechanics Ltd (Cyprus).

July 2014 - A strategy for grouping of nanomaterials based on key physico-chemical descriptors as a basis for safer-by-design NMs. Iseult Lynch, Carsten Weiss, Eugenia Valsami-Jones, University of Birmingham & Karlsruhe Institute of Technology. nanotoday. Online since 5 July 2014.